effect:
1)on SMT
prolong duration,and decrease amplitude
2)on muscle
~fatigue of excitation coupling mechanism
~increase metabolite
~increase oxygen,decrease carbon dioxide
~decrease active transport of Ca++ to SR
~decrease energy
~decrease ATP,Cr-P,glycogen
~disturbance of pH
~disturbance of electrolyte
causes:
metabolite..
decrease ATP,Cr-P,glycogen
chemical..
decrease oxygen,increase carbon dioxide,decrease neuromuscular transmission
sites:
direct..
at the MEP by ATP
indirect...
at NMJ by chemical transmitter
